Detection of correlated hidden factors from single cell transcriptomes using Iteratively Adjusted-SVA (IA-SVA)
نویسندگان
چکیده
منابع مشابه
Mapping SVA to PSL
Note that local variables and first match are not in the domain of the mapping. Throughout, “unclocked SVA sequence” means “unclocked SVA sequence without local variables or first match”. Similarly, “clocked SVA sequence” means “clocked SVA sequence without local variables or first match”. In the following abstract grammars, b denotes a boolean expression, v denotes a local variable name, and e...
متن کاملFrom Löwenheim to PSL and SVA
One of the surprising developments in the area of program verification is how ideas introduced by logicians in the early part of the 20th Century ended up yielding by the 21 Century industrial-standard property-specification languages. This development was enabled by the equally unlikely transformation of the mathematical machinery of automata on infinite words, introduced in the early 1960s fo...
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Endogenous mobile genetic elements can give rise to de novo germline or somatic mutations that can have dramatic consequences for genome regulation both local and possibly more globally based on the site of integration. However if we consider them as "normal genetic" components of the reference genome then they are likely to modify local chromatin structure which would have an effect on gene re...
متن کاملSVA elements: a hominid-specific retroposon family.
SVA is a composite repetitive element named after its main components, SINE, VNTR and Alu. We have identified 2762 SVA elements from the human genome draft sequence. Genomic distribution analysis indicates that the SVA elements are enriched in G+C-rich regions but have no preferences for inter- or intragenic regions. A phylogenetic analysis of the elements resulted in the recovery of six subfam...
متن کاملSVA: software for annotating and visualizing sequenced human genomes
SUMMARY Here we present Sequence Variant Analyzer (SVA), a software tool that assigns a predicted biological function to variants identified in next-generation sequencing studies and provides a browser to visualize the variants in their genomic contexts. SVA also provides for flexible interaction with software implementing variant association tests allowing users to consider both the bioinforma...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-35365-9